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Peptide record

TPDB92654

PN227 (SEQ ID NO: 37) PN275 (SEQ ID NO: 37) Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB92654
PN227 (SEQ ID NO: 37) PN275 (SEQ ID NO: 37)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Maleimide addition
Sequence
AAVALLPAVLLALLAPRKKRRQRRRPPQ-NH2
Physicochemical Analysis
C142H256N50O31
NDCEGHIMFSTWY
ARL
3159.91
13.10
8
0
14
+8
5.56
-0.221
125.71
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
6
A
6
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
6
L
2
K
0
M
0
F
4
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 6 K: 2 M: 0 F: 0 P: 4 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C142H256N50O31
3159.91
13.10
+8
5.56
-0.221
Amidation
L
Linear
Maleimide addition
N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CGGGHHHHHTTTCSSSSSCCSSCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CGGGHHHHHTTTCSSSSSCCSSCCCCCC
Additional Detail Fields 1 fields
CGGGHHHHHTTTCSSSSSCCSSCCCCCC