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Peptide record

TPDB92648

RA-PepB2 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92648
RA-PepB2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Retinoylated
Sequence
AAAAEKAAAAEK
Physicochemical Analysis
C46H80N14O17
RNDCQGHILMFPSTWYV
A
1101.22
7.06
2
2
8
+0
4.66
-0.033
66.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C46H80N14O17
1101.22
7.06
+0
4.66
-0.033
Free
L
Linear
Retinoylated
N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rencell Vm Immortalized Human Neural Stem Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Carboxytetramethylrhodamine (TAMRA) or 5-Carboxy-X-rhodamine (ROX)
34-fold increased uptake (82% of cells) compared with the control
Endocytosis
In vitro
CCSSCC
Additional Detail Fields 1 fields
CCSSCC