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Peptide record

TPDB92642

R-Rfa Blood-Brain Barrier Neuropeptide standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92642
R-Rfa
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
B3Pred BBPpredict Peptipedia
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Chemical: 5(6)-carboxyfluorescein attched to peptide
Sequence
SLKPAANLPLRF
Physicochemical Analysis
C62H103N17O15
DCEQGHIMTWYV
L
1326.60
11.49
2
0
6
+2
0.10
0.158
114.17
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
1
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 1 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C62H103N17O15
1326.60
11.49
+2
0.10
0.158
5(6)-carboxyfluorescein attched to peptide
Linear
Similarity
SerLeuLysProAlaAlaAsnLeuProLeuArgPhe
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Fourier Transform Infrared Spectroscopy
Inhibition of Aβ fibrillation
Alzheimer’s disease

Source & Reference

NA
B3Pdb

Other

Dodeca-neuropeptide (SLKPAANLPLRF) of frog brain.
Intraperitoneal
It inhibits Aβ fibrillization, moderately binds with tubulin and promotes tubulin polymerization as
Additional Detail Fields 1 fields
Intraperitoneal