TPDB

3D PDB MODEL

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TPDB ID TPDB92635

Peptide_Name

Arginine vasopressin Vasopressin

Activity

Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Modification

Chemical: Cys1-Cys6

Sequence

CYFQNCPRG

FASTA

>TPDB92635|Blood-Brain Barrier;Neuropeptide|length=9
CYFQNCPRG

Formula C46H66N14O13S2

Absent Amino Acids ADEHILKMSTWV

Common Amino Acids C

Mass 1087.24

PI 8.28

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index -0.28

Hydrophobicity -0.778

Aliphatic Index 0.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 148.54

Polar Residues 5

number

0

A

1

R

1

N

0

D

2

C

0

E

1

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

9

Formula

C46H66N14O13S2

Mass

1087.24

PI

8.28

Net Charge

+1

Boman Index

-0.28

Hydrophobicity

-0.778

Chemical_Modification

Cys1-Cys6

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly

SMILES

O=C(O)CNC(=O)[C@@H](NC(=O)[C@@H]4N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)Cc3ccccc3)CCC(=O)N)CC(=O)N)CCC4)CCCNC(=[N@H])N C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00011 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00827 ml/g

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response Capillary depletion (parenchyma/serum)

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat

Transport Type Saturable

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In_Vivo_Mode_of_Delivery

Intravenous in situ brain perfusion Intracarotid injection