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Peptide record

TPDB92632

Pancreatic Polypepti Blood-Brain Barrier Neuropeptide standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB92632
Pancreatic Polypepti
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
BBPpredict Peptipedia
standard
No
A 36-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
APLEPEYPGDNATPEQMAQYAAELRRYINMLTRPRY
Physicochemical Analysis
C186H286N52O57S2
CHKFSWV
AP
4226.75
4.79
4
5
15
-1
10.03
-0.994
57.22
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5960
141.01
10
Residue Composition
number
5
A
4
R
2
N
1
D
0
C
4
E
2
Q
1
G
0
H
1
I
3
L
0
K
2
M
0
F
5
P
0
S
2
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 5 R: 4 N: 2 D: 1 C: 0 E: 4 Q: 2 G: 1 H: 0 I: 1 L: 3 K: 0 M: 2 F: 0 P: 5 S: 0 T: 2 W: 0 Y: 4 V: 0
Chemical Descriptors
36
C186H286N52O57S2
4226.75
4.79
-1
10.03
-0.994
Chemical modification
Linear
C-terminal modification
Similarity
Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr
[H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
43.6 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

human
non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.016 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

human
non saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00115 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

human
Intravenous
Saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.0131 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

human
Intravenous
Permeability
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.065 %/g

Assay & Model

Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

human
Intravenous
Permeability
Direct iodination
Additional Detail Fields 1 fields
Intravenous