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Peptide record

TPDB92627

MPG Mutant MPGNLS Antiviral Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92627
MPG Mutant MPGNLS
Antiviral Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AVPpred-BWR CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 27-aa standard natural multi-activity (Antiviral and Cell-penetrating Peptides) peptide sequence curated from AVPpred-BWR, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
C-terminal: Cysteamide group N-terminal: Acetylation
Sequence
Ac-GALFLGFLGAAGSTMGAWSQPKSKRKV
Physicochemical Analysis
C126H201N35O33S1
NDCEHIY
G
2766.26
11.73
4
0
12
+4
-1.24
0.111
68.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
198.82
5
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
5
G
0
H
0
I
3
L
3
K
1
M
2
F
1
P
3
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 3 K: 3 M: 1 F: 2 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
27
C126H201N35O33S1
2766.26
11.73
+4
-1.24
0.111
Cysteamide group
L
Amphipathic
Linear
Acetylation
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HS-68, Cos-7 and HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
Fluorophore (fluorescein)
Nucleus
Lower than wilde type MPG
Non-endocytic mechanism
In vitro
CCCCTTTTTTSSCSSSSSSSSSSSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HDFs

Assay & Model

female Sprague-Dawley rats
female Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro and in vivo
CCCCTTTTTTSSCSSSSSSSSSSSSCC
Additional Detail Fields 1 fields
CCCCTTTTTTSSCSSSSSSSSSSSSCC