TPDB

3D PDB MODEL

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TPDB ID TPDB92619

Peptide_Name

Peptide 2a

Activity

ACE inhibitors Anticancer Antihypertensive Bitter iDPPIV

Activity_category_statistics

Cardiometabolic peptides Cancer-related peptides Food sensory peptides

Database_Source

Peptipedia CancerPPD 2.0 AHTPDB Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (ACE inhibitors, Anticancer, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, AHTPDB, and other sources, with an available 3D structural model.

Modification

N-terminal: 4-(methylsulfonyl)benzoic acid

Sequence

YE

FASTA

>TPDB92619|ACE inhibitors;Anticancer;Antihypertensive;Bitter;iDPPIV|length=2
YE

Formula C14H18N2O6

Absent Amino Acids ARNDCQGHILKMFPSTWV

Common Amino Acids EY

Mass 310.31

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index 1.08

Hydrophobicity -2.400

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 480.17

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

2

Formula

C14H18N2O6

Mass

310.31

PI

3.29

Net Charge

-1

Boman Index

1.08

Hydrophobicity

-2.400

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

4-(methylsulfonyl)benzoic acid

Nature

Antiproliferative, Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 16.0 ± 0.13 µM

Detail Source Activity Anticancer

Activity Measurement 16.0

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 31.1 ± 0.03 µM

Detail Source Activity Anticancer

Activity Measurement 31.1

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 20.6 ± 0.03 µM

Detail Source Activity Anticancer

Activity Measurement 20.6

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017