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Peptide record

TPDB92606

BF2d Anticancer Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB92606
BF2d
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 Peptipedia SATPdb dbACP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 24-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
C-terminal: Conjugation with Texas Red
Sequence
TRSSRAGLQWPVGRVHRLLRKGGC
Physicochemical Analysis
C115H196N44O29S1
NDEIMFY
R
2691.16
12.58
7
0
7
+6
3.67
-0.642
77.08
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
204.37
5
Residue Composition
number
1
A
5
R
0
N
0
D
1
C
0
E
1
Q
4
G
1
H
0
I
3
L
1
K
0
M
0
F
1
P
2
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 4 H: 1 I: 0 L: 3 K: 1 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
24
C115H196N44O29S1
2691.16
12.58
+6
3.67
-0.642
Conjugation with Texas Red
L
Antimicrobial
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa or TM12 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Antimicrobial
Protein derived
Fluorophore (Texas Red)
Cytosol and nucleus
Comparable to Tat (47-57)
Unknown probably non endocytic pathway
In vitro
CCCCCCTTSCCTTTCCTTTSCCC
Additional Detail Fields 1 fields
CCCCCCTTSCCTTTCCTTTSCCC