Back to search

Peptide record

TPDB92603

PC5-52 Anticancer Antiviral Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92603
PC5-52
Anticancer Antiviral Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides
Peptipedia AI4AVP DRAVP 2.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer, Antiviral, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, AI4AVP, DRAVP 2.0, and other sources, with an available 3D structural model.
N-terminal: Biotinylation
Sequence
SVSVGMKPSPRP
Physicochemical Analysis
C53H92N16O16S1
ANDCEQHILFTWY
PS
1241.47
11.49
2
0
3
+2
3.46
-0.475
48.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
1
M
0
F
3
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C53H92N16O16S1
1241.47
11.49
+2
3.46
-0.475
PSP
Biotinylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Lung and Prostate cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.
US/ 20100119444A1,US 2010/0260673A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice human cancers including human lung (H460), colon (HCT116), breast (BT483), prostate (PC3), liver (Mahlavu), and pancreatic (PaCa) cancer xenografts
Phage display library
M13 phage/random peptide library
Doxorubicin
Additional Detail Fields 4 fields
Doxorubicin
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice human cancers including human lung (H460), colon (HCT116), breast (BT483), prostate (PC3), liver (Mahlavu), and pancreatic (PaCa) cancer xenografts
M13 phage/random peptide library