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Peptide record

TPDB92592

IDP-NS16 Anticancer standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92592
IDP-NS16
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 17-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Chemical: -(CH2)6-CH=CH-(CH2)3 Chemical: a biradical linker links R(8) and R(15)
Sequence
RQRRNDLRSSFLTLRDH
Physicochemical Analysis
C90H152N36O27
ACEGIKMPWYV
R
2170.42
12.22
6
2
4
+3
6.06
-1.635
68.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
5
R
1
N
2
D
0
C
0
E
1
Q
0
G
1
H
0
I
3
L
0
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 3 K: 0 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C90H152N36O27
2170.42
12.22
+3
6.06
-1.635
Free
-(CH2)6-CH=CH-(CH2)3 a biradical linker links R(8) and R(15)
L
Linear
Free
Anticancer
Synthetic
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
EC50 ~ 15 µM
Anticancer
15 µM

Target

Glioblastoma
RG1
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

EC50
EC50 ~ 10 µM
Anticancer
10 µM

Target

Glioblastoma
12053
Brain

Assay & Model

AlamarBlue assay
72-96 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
WO 2019/025432 Al