Back to search

Peptide record

TPDB92578

bombesin Anticancer Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92578
bombesin
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 13-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
C-terminal: 1,2,3-triazoles N-terminal: azide
Sequence
QRLGNQWAVGHLM
Physicochemical Analysis
C66H104N22O17S1
DCEIKFPSTY
QGL
1509.75
11.05
2
0
6
+1
0.07
-0.338
90.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5500
364.30
3
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
0
E
2
Q
2
G
1
H
0
I
2
L
0
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 0 L: 2 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C66H104N22O17S1
1509.75
11.05
+1
0.07
-0.338
1,2,3-triazoles
azide
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
gastrin releasing peptide receptor (GRPr)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Probing the Backbone Function of Tumor Targeting Peptides by an Amide-to-Triazole Substitution Strategy
2015
Ibai E. Valverde et al. J Med Chem. 2015 Sep 24. 58(18) 7475-84

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
PC-3, AR42J cells
6−8 weeks old female athymic nude Foxn1nu mice (20−25 g)
Synthetic
macrocyclic chelator 1,4,7,10 tetra aza cyclo dodecane-1,4,7,10-tetra acetic acid (DOTA)
Additional Detail Fields 3 fields
macrocyclic chelator 1,4,7,10 tetra aza cyclo dodecane-1,4,7,10-tetra acetic acid (DOTA)
PC-3, AR42J cells
6−8 weeks old female athymic nude Foxn1nu mice (20−25 g)