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Peptide record

TPDB92572

p28 Anticancer Antiviral Cell-penetrating Peptides Tumor-homing Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB92572
p28
Anticancer Antiviral Cell-penetrating Peptides Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 DRAVP 2.0 CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 28-aa standard natural multi-activity (Anticancer, Antiviral, Cell-penetrating Peptides, and other sources) peptide sequence curated from CancerPPD 2.0, DRAVP 2.0, CPPsite3.0, and other sources, with an available 3D structural model.
Chemical: Indocyanine green (ICG)
Sequence
LSTAADMQGVVTDGMASGLDKDYLKPDD
Physicochemical Analysis
C122H197N31O47S2
RNCEHIFW
D
2914.21
3.58
2
6
11
-4
7.51
-0.371
73.21
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
51.13
6
Residue Composition
number
3
A
0
R
0
N
6
D
0
C
0
E
1
Q
3
G
0
H
0
I
3
L
2
K
2
M
0
F
1
P
2
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 6 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 3 K: 2 M: 2 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C122H197N31O47S2
2914.21
3.58
-4
7.51
-0.371
Free
Indocyanine green (ICG)
L
Anionic
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ln-229 And U-118 Cells And Astrocytes And Fibroblasts

Assay & Model

Athymic mice at 4-5 weeks old
Athymic mice at 4-5 weeks old

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Protein derived
Alexa fluor 568 labelled Gold nanoparticles (GNPs) loaded with temozolomide (TMZ)
Cytosol, Nucleus and Endosomes
Alexa Fluor 568 labelled p28 showed that p28 preferentially entered GBM cell lines whereas minimal signal was detected from astrocytes and fibroblasts.
In vitro and in vivo
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC