Back to search

Peptide record

TPDB92571

F3 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92571
F3
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 32-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
C-terminal: an extra Cysteine
Sequence
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKKC
Physicochemical Analysis
C155H268N50O42S1
NGHIMFTWYV
KP
3536.20
10.96
11
3
6
+8
18.41
-1.806
27.81
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
5
A
3
R
0
N
1
D
1
C
2
E
1
Q
0
G
0
H
0
I
1
L
8
K
0
M
0
F
8
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 0 D: 1 C: 1 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 8 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C155H268N50O42S1
3536.20
10.96
+8
18.41
-1.806
an extra Cysteine
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
triple-negative Breast cancer
Nucleolin

Source & Reference

TumorHoPe2.0
TumorHoPe2
A carbon monoxide releasing metal organic framework nanoplatform for synergistic treatment of triple-negative breast tumors
2022
Yiyang Cong et al. J Nanobiotechnology. 2022 Nov 24 20(1):494.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231 cell line, L929 murine fibroblasts
BALB/c Female nude mice (6–10 weeks)
Synthetic
Carbon monoxide (CO), Tirapazamine (TPZ), Polyacrylic acid-polyethylene glycol (Py-PAA-PEG), Zirconium-89 (89Zr)
Additional Detail Fields 3 fields
Carbon monoxide (CO), Tirapazamine (TPZ), Polyacrylic acid-polyethylene glycol (Py-PAA-PEG), Zirconium-89 (89Zr)
MDA-MB-231 cell line, L929 murine fibroblasts
BALB/c Female nude mice (6–10 weeks)