TPDB

3D PDB MODEL

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TPDB ID TPDB92568

Peptide_Name

IF7

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

AntiCP 2.0 Peptipedia iACP-DRLF pep-lab StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from AntiCP 2.0, Peptipedia, iACP-DRLF, and other sources, with an available 3D structural model.

Modification

C-terminal: C -terminal modification for linking drugs and fluorophore A488

Sequence

IFLLWQR

FASTA

>TPDB92568|Anticancer;Tumor-homing Peptides|length=7
IFLLWQR

Formula C49H74N12O9

Absent Amino Acids ANDCEGHKMPSTYV

Common Amino Acids L

Mass 975.20

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index -3.02

Hydrophobicity 0.857

Aliphatic Index 167.14

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 563.99

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

2

L

0

K

0

M

1

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

7

Formula

C49H74N12O9

Mass

975.20

PI

11.05

Net Charge

+1

Boman Index

-3.02

Hydrophobicity

0.857

C_terminal_Modification

C -terminal modification for linking drugs and fluorophore A488

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Lung carcinoma, Prostate cancer, Breast Cancer, Colon cancer

Receptors Biomarker Anxa1

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide.

Year 2011

Reference

Hatakeyama S et al. Proc Natl Acad Sci U S A.2011 Dec 6 108(49):19587-92.

Patent US 7,470,658 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model Nude mice bearing HCT116 tumors,C57BL6 mice bearing B16F1 and Lewis lung carcinoma,SCID mice bearing prostate tumor

Source Type Synthetic

Conjugate Payload Alexa 488 (A488), Drug SN-38 , 17-AAG (GA), a geldanamycin analogue

Conjugate_Payload

Alexa 488 (A488), Drug SN-38 , 17-AAG (GA), a geldanamycin analogue

InVivo_Model

Nude mice bearing HCT116 tumors,C57BL6 mice bearing B16F1 and Lewis lung carcinoma,SCID mice bearing prostate tumor