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Peptide record

TPDB92554

MPG Anticancer Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92554
MPG
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 27-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
GALFLGFLGAAGSTMGAWSQPKKKRKV
Physicochemical Analysis
C129H208N36O32S1
NDCEHIY
G
2807.35
11.80
5
0
12
+5
-0.38
-0.004
68.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
195.91
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
5
G
0
H
0
I
3
L
4
K
1
M
2
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 3 K: 4 M: 1 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
27
C129H208N36O32S1
2807.35
11.80
+5
-0.38
-0.004
Free
Nanoparticles
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1 N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cos-7 Cell Line

Assay & Model

Inbred C57BL/6 female mice, 5–7 week old,
Inbred C57BL/6 female mice, 5–7 week old,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
HPV16 E7 DNA
MPG/DNA nanoparticles facilitate the uptake of DNA by cells as strong E7-GFP expression was detected in approximately 66% of COS-7 cells treated with an N/P ratio of 10:1.
In vitro and in vivo
CCSSCCCCCCCCCCCSSCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek 293 T Cell

Assay & Model

Inbred Balb/c female mice, 6–8-week old
Inbred Balb/c female mice, 6–8-week old

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
pcDNA-core and pcDNA-coreE1E2
A dominant band of 21 kDa in transfected cells expressing core and also a clear band of 83 kDa in transfected cells expressing coreE1E2 that they were not detected in the untransfected cells.
In vitro and in vivo
CCBTTBCSSCCCCBTTBCCC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCCSSCCCC CCBTTBCSSCCCCBTTBCCC