TPDB

3D PDB MODEL

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TPDB ID TPDB92547

Peptide_Name

DUP-1 peptide

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Modification

C-terminal: Lysine added in the C-terminal for FITC conjugation

Sequence

FRPNRAQDYNTN

FASTA

>TPDB92547|Anticancer;Tumor-homing Peptides|length=12
FRPNRAQDYNTN

Formula C63H94N22O21

Absent Amino Acids CEGHILKMSWV

Common Amino Acids N

Mass 1495.57

PI 9.87

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 3.04

Hydrophobicity -2.125

Aliphatic Index 8.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 99.63

Polar Residues 6

number

1

A

2

R

3

N

1

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

12

Formula

C63H94N22O21

Mass

1495.57

PI

9.87

Net Charge

+1

Boman Index

3.04

Hydrophobicity

-2.125

C_terminal_Modification

Lysine added in the C-terminal for FITC conjugation

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Prostate carcinomas

Receptors Biomarker Prostate-specific membrane antigen

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title A new prostate carcinoma binding peptide (DUP-1) for tumor imaging and therapy

Year 2005

Reference

Zitzmann S et al. Clin Cancer Res. 2005 Jan 1 11(1):139-46.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Prostate-specific membrane antigen?â?ó?ó?ÇÜ?¼?ó?é¼?ônegative cell line DU-145 ,HUVEC

InVivo Model Male 6-week-old BALB/c mice and Copenhagen rats weighing 220 to 250 g

Source Type Phage display library

Phage Display Library M13 phage /12 mer peptide library

Conjugate Payload Radioisotope131

Conjugate_Payload

Radioisotope131

InVitro_ExVivo

Prostate-specific membrane antigen?â?ó?ó?ÇÜ?¼?ó?é¼?ônegative cell line DU-145 ,HUVEC

InVivo_Model

Male 6-week-old BALB/c mice and Copenhagen rats weighing 220 to 250 g

Phage_Display_Library

M13 phage /12 mer peptide library