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Peptide record

TPDB92541

Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92541
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia and TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidated
Sequence
CVNHPAFAC
Physicochemical Analysis
C41H60N12O11S2
RDEQGILKMSTWY
AC
961.12
7.00
1
0
4
-0
-0.05
0.811
54.44
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.01
3
Residue Composition
number
2
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C41H60N12O11S2
961.12
7.00
-0
-0.05
0.811
Amidated
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Hepatocellular carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment
2019
Ying Zan et al. Drug Deliv. 2019 Dec 26(1):1080-1091.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human liver cancer cell line (HepG2), Sorafenib-resistant HepG2/SOR cells
Male nude Balb/c mice (18–20g)
Synthetic
TAT(cell membrane penetrating peptide), Plantamajoside (PMS), Sorafenib (SOR), PLA-based nanoparticles
Additional Detail Fields 3 fields
TAT(cell membrane penetrating peptide), Plantamajoside (PMS), Sorafenib (SOR), PLA-based nanoparticles
Human liver cancer cell line (HepG2), Sorafenib-resistant HepG2/SOR cells
Male nude Balb/c mice (18–20g)