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Peptide record

TPDB92520

CPIEDRPMCGGSK(F) Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92520
CPIEDRPMCGGSK(F)
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
C-terminal: Attachment at C-terminus by the sequence ?â?ó?ó?ÇÜ?¼?ï?ôGGSK
Sequence
CPIEDRPMC
Physicochemical Analysis
C42H70N12O14S3
ANQGHLKFSTWYV
CP
1063.27
4.07
1
2
2
-1
3.94
-0.367
43.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
11.76
2
Residue Composition
number
0
A
1
R
0
N
1
D
2
C
1
E
0
Q
0
G
0
H
1
I
0
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 2 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C42H70N12O14S3
1063.27
4.07
-1
3.94
-0.367
Attachment at C-terminus by the sequence ?â?ó?ó?ÇÜ?¼?ï?ôGGSK
RPMC
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Extra cellular matrix
Homing
Colon cancer
Alpha -5 beta-1 ( Fibronectin binding partner)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide
2004
Kelly K et al. Cancer Res. 2004 Sep 1 64(17):6247-51.
US 2007/0219134A1,US 2006/0058228A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HT29 cell line, CT 26 cells , multiple human biopsy samples
C57Bl/6 wild-type mice (7 to 9 weeks) bearing colon cancer cell HT29 xenograft
Synthetic
Radioactive indium chelated by a DOTA group
pmid
Additional Detail Fields 3 fields
Radioactive indium chelated by a DOTA group
HT29 cell line, CT 26 cells , multiple human biopsy samples
C57Bl/6 wild-type mice (7 to 9 weeks) bearing colon cancer cell HT29 xenograft