TPDB

3D PDB MODEL

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TPDB ID TPDB92516

Peptide_Name

CLT2

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-CNAGESSKNC-NH2

FASTA

>TPDB92516|Anticancer;Tumor-homing Peptides|length=10
Ac-CNAGESSKNC-NH2

Formula C36H61N13O17S2

Absent Amino Acids RDQHILMFPTWYV

Common Amino Acids NCS

Mass 1012.08

PI 6.14

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 3.47

Hydrophobicity -0.960

Aliphatic Index 10.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 12.35

Polar Residues 6

number

1

A

0

R

2

N

0

D

2

C

1

E

0

Q

1

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C36H61N13O17S2

Mass

1012.08

PI

6.14

Net Charge

-0

Boman Index

3.47

Hydrophobicity

-0.960

C_terminal_Modification

Amidation

N_terminal_Modification

Acetylation

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel, Tumor cell, Endothelial cell

Homing or Targeting Homing

Target Tumor Melanoma, Breast cancer, Prostate cancer, Lung cancer

Receptors Biomarker fibronectin

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions related to targeting tumors and wounds

Year 2016

Reference

US 9522198 B2

Patent US 9522198 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, PPC-1 human prostate cancer cells

InVivo Model C57BL/6 mice, BALB/c nu/nu mice

Source Type Phage Display library

Phage Display Library T7 10-3b phage/ CX8C peptide library

InVitro_ExVivo

B16F1 mouse melanoma, Lewis lung carcinoma, C8161 human melanoma, MDA-MB-435 human breast cancer, PPC-1 human prostate cancer cells

InVivo_Model

C57BL/6 mice, BALB/c nu/nu mice

Phage_Display_Library

T7 10-3b phage/ CX8C peptide library