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Peptide record

TPDB92506

Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB92506
Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia B3Pred BBPpredict CPPsite3.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, B3Pred, BBPpredict, and other sources, with an available 3D structural model.
N-terminal: Cysteine
Sequence
CGKRK
Physicochemical Analysis
C23H46N10O6S1
ANDEQHILMFPSTWYV
K
590.74
10.59
3
0
0
+3
2.56
-2.040
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H46N10O6S1
590.74
10.59
+3
2.56
-2.040
Cysteine
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor endothelial cell, tumor cell
Homing
Glioblastoma, Breast cancer
Alpha-5 beta -3, Alpha-5 beta -5, Alpha-5 beta-1 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment
2017
Sharma S et al. J Control Release. 2017 Dec 28:268:49-56

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MCF10CA1a human breast tumor cell line
BALB/c nude mice
Phage Display Library
CX7C naïve phage library
5(6)-fluorescein carboxylate (FAM)
Additional Detail Fields 4 fields
5(6)-fluorescein carboxylate (FAM)
MCF10CA1a human breast tumor cell line
BALB/c nude mice
CX7C naïve phage library