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Peptide record

TPDB92505

cpp Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB92505
cpp
Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia B3Pred BBPpredict CPPsite3.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, B3Pred, BBPpredict, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: FITC at N-terminus via the 6-aminohexanoic acid linker.
Sequence
CGKRK-NH2
Physicochemical Analysis
C23H46N10O6S1
ANDEQHILMFPSTWYV
K
590.74
10.59
3
0
0
+3
2.56
-2.040
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H46N10O6S1
590.74
10.59
+3
2.56
-2.040
Amidation
FITC at N-terminus via the 6-aminohexanoic acid linker.
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mb49 Cells And Murine Peritoneal Macrophages

Assay & Model

8 to 12-week-old female mice (C57BL/6 or BALB/c)
8 to 12-week-old female mice (C57BL/6 or BALB/c)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Phage Display
Rhodamine B nanogel
Cytoplasm
CGKRK accumulated in cells almost 10-fold more efficiently than KAREC.
In vitro and in vivo