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Peptide record

TPDB92501

APRPG peptide Anticancer Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB92501
APRPG peptide
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia and TumorHoPe2.0, with an available 3D structural model.
N-terminal: Addition of PEI-PEG at N terminus
Sequence
APRPG
Physicochemical Analysis
C21H36N8O6
NDCEQHILKMFSTWYV
P
496.57
11.05
1
0
1
+1
1.55
-1.260
20.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C21H36N8O6
496.57
11.05
+1
1.55
-1.260
Addition of PEI-PEG at N terminus
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Breast cancer
VEGF

Source & Reference

TumorHoPe2.0
TumorHoPe2
Development of small interfering RNA delivery system using PEI-PEG-APRPG polymer for antiangiogenic vascular endothelial growth factor tumor-targeted therapy
2011
Lu ZX et al. Int J Nanomedicine 2011 6:1661-73.
US 6,753,310 B1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human breast cancer cell line MCF-7
BALB/C nude mice (5 weeks of age)
Synthetic
Additional Detail Fields 2 fields
Human breast cancer cell line MCF-7
BALB/C nude mice (5 weeks of age)