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Peptide record

TPDB92495

LALF32-51 Cell-penetrating Peptides Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB92495
LALF32-51
Cell-penetrating Peptides Hemolysis Toxicity
Toxicity and safety peptides Delivery and barrier-penetrating peptides
CPPsite3.0 HemoPI Hemolytic2 Peptipedia
standard
No
A 20-aa standard natural multi-activity (Cell-penetrating Peptides, Hemolysis, and Toxicity) peptide sequence curated from CPPsite3.0, HemoPI, Hemolytic2, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
HYRIKPTFRRLKWKYKGKFW-NH2
Physicochemical Analysis
C135H200N38O24
ANDCEQMSV
K
2739.31
11.62
9
0
8
+8
0.23
-1.470
39.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
13980
510.35
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
1
L
5
K
0
M
2
F
1
P
0
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 5 M: 0 F: 2 P: 1 S: 0 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
20
C135H200N38O24
2739.31
11.62
+8
0.23
-1.470
Amidation
L
Amphipathic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Balb/c female mice (H-2d haplotype) of 8 to 12 weeks
Balb/c female mice (H-2d haplotype) of 8 to 12 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Recombinant hepatitis B surface protein (HBsAg)
Cytoplasm and Endosomes
Superior IgG response than TAT
Direct translocation
In vivo
CTTTTHHHHHHHHTTTCC
Additional Detail Fields 1 fields
CTTTTHHHHHHHHTTTCC