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Peptide record

TPDB92475

low molecular weight protamine (LMWP) Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92475
low molecular weight protamine (LMWP)
Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP B3Pred BBPpredict CellPPD-MOD CPPsite3.0 PerseuCPP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Chemical: Sulfhydrylation N-terminal: Sulfhydrylation
Sequence
VSRRRRRRGGRRRR
Physicochemical Analysis
C72H142N44O16
ANDCEQHILKMFPTWY
R
1880.20
13.35
10
0
1
+10
8.32
-3.029
20.71
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C72H142N44O16
1880.20
13.35
+10
8.32
-3.029
Free
Sulfhydrylation
L
Cationic
Linear
Sulfhydrylation
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 cell culture

Assay & Model

Male Wistar rats
Male Wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
Protein (Insulin-PEG-LMWP)
Equivalent cell-internalization potency to that of TAT
In vitro and in vivo
CCSSSSSSGGGSCC
Additional Detail Fields 1 fields
CCSSSSSSGGGSCC