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Peptide record

TPDB92474

CPP (Smac-CPP) Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92474
CPP (Smac-CPP)
Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP B3Pred BBPpredict CellPPD-MOD CPPsite3.0 PerseuCPP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Chemical: Smac
Sequence
VSRRRRRRGGRRRR
Physicochemical Analysis
C72H142N44O16
ANDCEQHILKMFPTWY
R
1880.20
13.35
10
0
1
+10
8.32
-3.029
20.71
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C72H142N44O16
1880.20
13.35
+10
8.32
-3.029
Free
Smac
L
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 Cells

Assay & Model

Balb/c mice breast 4T1 tumor cells
Balb/c mice breast 4T1 tumor cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Cyanine-3 labelled PLGA nanoparticles (NPs)
Cytosol
Cy3-NP-(Smac-CPP) were rapidly internalized by 4T1 cells after 2 h of incubation
In vitro and in vivo
CCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCC