TPDB

3D PDB MODEL

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TPDB ID TPDB92470

Peptide_Name

LL-III/4

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

VNWKKILGKIKKVVK-NH2

FASTA

>TPDB92470|Antibacterial;Anticancer;Antifungal;Toxicity|length=15
VNWKKILGKIKKVVK-NH2

Formula C86H153N23O17

Absent Amino Acids ARDCEQHMFPSTY

Common Amino Acids K

Mass 1781.30

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +6

Boman Index 3.55

Hydrophobicity -0.187

Aliphatic Index 136.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 308.76

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

2

I

1

L

6

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

3

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3

Length

15

Formula

C86H153N23O17

Mass

1781.30

PI

11.21

Net Charge

+6

Boman Index

3.55

Hydrophobicity

-0.187

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Lasioglossin III and its analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 7±1 µM

Detail Source Activity Anticancer

Activity Measurement 7

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 40 µM

Detail Source Activity Anticancer

Activity Measurement 40 µM

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 18 µM

Detail Source Activity Anticancer

Activity Measurement 18 µM

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012