Back to search

Peptide record

TPDB92463

Rev Antibacterial Antiviral Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92463
Rev
Antibacterial Antiviral Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 CellPPD CPPsite3.0 PerseuCPP
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antiviral, and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-TRQARRNRRRRWRERQR-NH2
Physicochemical Analysis
C97H173N51O24
DCGHILKMFPSYV
R
2437.77
13.00
10
1
2
+9
9.82
-3.459
5.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
225.62
4
Residue Composition
number
1
A
10
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 10 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C97H173N51O24
2437.77
13.00
+9
9.82
-3.459
Amidation
L
Amphipathic Cationic
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wild Type CHO (CHO-K1) Cells And The Gag-Deficient CHO Cells (Pgsa-745)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein (FAM) via glycylglycine linker at N terminus
In vitro
CCTTSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
FAM via glycylglycine linker at N terminus
FAM-Rev significantly penetrate cell membranes and exhibited much greater efficiency of cell penetration than R8.
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC CCCCCCCC