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Peptide record

TPDB92453

heptaarginine (R7) Antibacterial Anticancer Antiviral Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92453
heptaarginine (R7)
Antibacterial Anticancer Antiviral Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, CellPPD, and other sources, with an available 3D structural model.
Chemical: NGR-modified
Sequence
RRRRRRR
Physicochemical Analysis
C42H86N28O8
ANDCEQGHILKMFPSTWYV
R
1111.33
13.18
7
0
0
+7
5.67
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H86N28O8
1111.33
13.18
+7
5.67
-4.500
Free
NGR-modified
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080 Cell

Assay & Model

HT-1080 tumor-bearing mouse model (Female Balb/c nude mice (age 4–6 weeks, body weight 20–25 g))
HT-1080 tumor-bearing mouse model (Female Balb/c nude mice (age 4–6 weeks, body weight 20–25 g))

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Chlorin e6 Phospholipid
Mitochondria
Accumulation increased 2-fold with NPh-Ce6-NGR-R7 and approximately 1.5-fold with the NPh-Ce6, as compared with free chlorin e6.
In vitro and in vivo
CCCGGGGCCCC
Additional Detail Fields 1 fields
CCCGGGGCCCC