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Peptide record

TPDB92437

TMR-R3 ACE inhibitors Antibacterial Antifungal Antihypertensive Bitter Cell-penetrating Peptides Hemolysis Toxicity standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB92437
TMR-R3
ACE inhibitors Antibacterial Antifungal Antihypertensive Bitter Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB Tastepeptides-Meta CPPsite3.0 PD_Hemolysis
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
N-terminal: Conjugation with TMR
Sequence
RRR
Physicochemical Analysis
C18H38N12O4
ANDCEQGHILKMFPSTWYV
R
486.58
12.70
3
0
0
+3
2.43
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C18H38N12O4
486.58
12.70
+3
2.43
-4.500
L
Cationic
Linear
Conjugation with TMR
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U251-MG, HeLa, HEK293 cells, LNZ308, K562 cells, Primary rat fibroblasts cells and U87 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (TMR)
Cytoplasm and nucleus
With pyrenebutyrate, p53-3R was mainly observed in the Nucleus whereas without pyrenebutyrate, it existed in the Cytoplasm
lipid raft dependent macropinocytosis
In vitro
CCC
Additional Detail Fields 1 fields
CCC