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Peptide record

TPDB92424

BR2 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92424
BR2
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia and CPPsite3.0, with an available 3D structural model.
Chemical: lipid linker (DSPE-PEG2000-maleimide) N-terminal: Addition of Cysteine
Sequence
RAGLQFPVGRLLRRLLR
Physicochemical Analysis
C91H161N33O19
NDCEHIKMSTWY
RL
2021.49
13.00
5
0
8
+5
1.07
-0.035
137.65
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
5
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 5 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C91H161N33O19
2021.49
13.00
+5
1.07
-0.035
Free
lipid linker (DSPE-PEG2000-maleimide)
L
Linear
Addition of Cysteine
N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 And Miha Cells

Assay & Model

HepG2 tumor model of Balb/c nude male mice (4-5 weeks, 18–20 g)
HepG2 tumor model of Balb/c nude male mice (4-5 weeks, 18–20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Liposomes loaded with CTD
Cytoplasm and nucleus
BR2-Lp-treated HepG2 cells had stronger fluorescent intensity than that in Miha cells
In vitro and in vivo
CTTTTCCTTTTGGGTCC
Additional Detail Fields 1 fields
CTTTTCCTTTTGGGTCC