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Peptide record

TPDB92421

R-DIM-P-LF11-334 Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92421
R-DIM-P-LF11-334
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PWRIRIRRPRRIRIWP-NH2
Physicochemical Analysis
C103H171N39O17
ANDCEQGHLKMFSTYV
R
2227.74
13.18
7
0
6
+7
2.08
-1.256
97.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
11000
493.77
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C103H171N39O17
2227.74
13.18
+7
2.08
-1.256
Amidation
L
Linear
Free
Anticancer
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

LC50
LC50 = 6.6 ± 0.3 µM
Anticancer
6.6

Target

Skin Cancer
A-375
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
EP_2943215_B1

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

LC50
LC50 = 3.4 ± 0.4 µM
Anticancer
3.4

Target

Skin Cancer
SBcl2
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
EP_2943215_B1
Evidence 3 Activity

Activity

LC50
LC50 = 5.0 ± 0.1 µM
Anticancer
5.0

Target

Skin Cancer
WM164
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
EP_2943215_B1