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Peptide record

TPDB92413

NLS Antibacterial Antifungal Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92413
NLS
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
PKKKRKV-NH2
Physicochemical Analysis
C40H78N14O8
ANDCEQGHILMFSTWY
K
883.15
11.80
5
0
1
+5
5.29
-2.500
41.43
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C40H78N14O8
883.15
11.80
+5
5.29
-2.500
Amidation
L
Cationic
Tetramer
Free
N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@H]1CC(=O)OOC(=O)[C@H]2N(C1=O)CCC2
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Br-3, Jimt-1, A431, Jurkat-Cells

Assay & Model

Athymic BALB/c nude mice xenografted A431tumors
Athymic BALB/c nude mice xenografted A431tumors

Source & Reference

CPPsite3.0
CPPsite3
EP2928502B1

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Tetramer L Cationic
Protein derived
Anti-EGFR mAb matuzumab (Mat)
Highest values as 37% for Mat-tNLS
Endocytosis
In vitro and in vivo
CGGGTTTTSSCC
Additional Detail Fields 1 fields
CGGGTTTTSSCC