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Peptide record

TPDB92412

R-DIM-LF11-337 Antibacterial Anticancer Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB92412
R-DIM-LF11-337
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PFWRRRIRIRRRRIRIRRRWFP-NH2
Physicochemical Analysis
C146H242N60O23
ANDCEQGHLKMSTYV
R
3205.92
13.44
12
0
8
+12
3.42
-1.609
70.91
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
11000
343.12
0
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
0
K
0
M
2
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
22
C146H242N60O23
3205.92
13.44
+12
3.42
-1.609
Amidation
L
Linear
Free
Host Defence Peptide
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

LC50
LC50 = 3.5 ± 0.4 µM
Anticancer
3.5

Target

Skin Cancer
A-375
Skin

Assay & Model

PI uptake assay
8-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

LC50
LC50 = 12.3 ± 1.3 µM
Anticancer
12.3

Target

Skin Cancer
A-375
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

LC50
LC50 = 5.0 ± 0.4 µM
Anticancer
5.0

Target

Skin Cancer
SBcl2
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015