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Peptide record

TPDB92410

PF Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB92410
PF
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 DRAVP 2.0 B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, DRAVP 2.0, and other sources, with an available 3D structural model.
Chemical: Transferrin (Tf)-modified DiI-labeled Liposomes
Sequence
PFVYLI
Physicochemical Analysis
C40H58N6O8
ARNDCEQGHKMSTW
ILFPYV
750.94
5.94
0
0
5
-0
-2.42
2.067
178.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
198.42
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C40H58N6O8
750.94
5.94
-0
-2.42
2.067
Free
Transferrin (Tf)-modified DiI-labeled Liposomes
L
Hydrophobic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, Glial, And Primary Neuronal Cells

Assay & Model

Male/female Sprague Dawley rats and C57BL/6 mice
Male/female Sprague Dawley rats and C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
pDNA
R9F2Tf-liposomes showed a superior ability to induce GFP expression in bEnd.3 (41.4% versus 24.1% for PFTf-lip), glial (25.8% versus 22.9% for PFTf-lip), and primary neuronal cells (13.9% versus 12.0% for PFTf-lip).
Clathrin mediated endocytosis
In vitro and in vivo
CCSCSCCCCCGGGGGGCCC
Additional Detail Fields 1 fields
CCSCSCCCCCGGGGGGCCC