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Peptide record

TPDB92406

PFV Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB92406
PFV
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 DRAVP 2.0 B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, DRAVP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Transferrin (Tf) liposomes
Sequence
PFVYLI-NH2
Physicochemical Analysis
C40H58N6O8
ARNDCEQGHKMSTW
ILFPYV
750.94
5.94
0
0
5
-0
-2.42
2.067
178.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
198.42
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C40H58N6O8
750.94
5.94
-0
-2.42
2.067
Amidation
Transferrin (Tf) liposomes
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, bEnd.3 And Glial Cells , In Vitro 3D Brain Tumor Model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Doxorubicin (Dox) and Erlotinib (Erlo)
Cytoplasm and nucleus
The Dox uptake from the Tf-PFV liposomes showed approximately 66%, 66%, and 65% and Erlo was found to be approximately 69%, 68%, and 64% in U87, bEnd.3, and Primary glial cells, respectively. Tf-PFV liposomes showed significantly higher (p < 0.05) cellular uptake compared to single ligand or plain liposomes.
Clathrin-mediated endocytosis as well as clathrin-coated vesicles.
In vitro
CCSSSSCSSCCHHHHHTTTCC
Additional Detail Fields 1 fields
CCSSSSCSSCCHHHHHTTTCC