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Peptide record

TPDB92396

[R9S-R14S-R17S]cT1 Antibacterial Anticancer Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92396
[R9S-R14S-R17S]cT1
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and PD_Hemolysis, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
KWCFRVCYSGICYSRCSG
Physicochemical Analysis
C92H136N26O24S4
ANDEQHLMPT
C
2118.49
8.70
3
0
6
+3
-3.04
0.106
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
412.09
9
Residue Composition
number
0
A
2
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
3
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C92H136N26O24S4
2118.49
8.70
+3
-3.04
0.106
Cyclized
L
Cyclic
Cyclized
Host Defense Peptide
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

CC50
CC50 = 11.8 ± 0.9 µM
Anticancer
11.8

Target

Skin Cancer
HT-144
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

CC50
CC50 = 11.1 ± 0.9 µM
Anticancer
11.1

Target

Skin Cancer
WM164
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

CC50
CC50 = 4.8 ± 0.3 µM
Anticancer
4.8

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019