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Peptide record

TPDB92391

Tachyplesin (Tpl) Tpl Antibacterial Anticancer Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB92391
Tachyplesin (Tpl) Tpl
Antibacterial Anticancer Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KWCFRVCYRGICYRRCRGK
Physicochemical Analysis
C107H169N37O22S4
ANDEQHLMPST
R
2453.99
10.36
7
0
6
+7
-0.01
-0.689
35.79
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
355.75
6
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
19
C107H169N37O22S4
2453.99
10.36
+7
-0.01
-0.689
Free
L
Cationic
Random coil Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg And T98G Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Random coil L Cationic
Protein derived
anti-miR210
Tpl exhibited maximal uptake at 5 microM, with 70% uptake efficiency in T98G cells
In vitro
CCCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Promastigotes From The Wild Type Leishmania Donovani (Ag83Wt Cells)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
EGFP plasmid
Cytosol
Peptide internalization at 10 min of incubation in promastigote cells starts at 1 μM concentration of Tpl, whereas at 5 μM increase to five-fold.
In vitro
CCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells , Triticum Aestivum Protoplasts, Root Tips, Coleoptiles And Hypocotyls

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
FITC dye
Nucleus
Time and concentration-dependent internalization
Direct membrane penetration
In vitro
Additional Detail Fields 1 fields
CCCCCCCCCC CCCCCCCC