TPDB

3D PDB MODEL

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TPDB ID TPDB92388

Peptide_Name

[Y8S-I11S]cT1

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

KWCFRVCSRGSCYRRCRG

FASTA

>TPDB92388|Antibacterial;Anticancer;Toxicity|length=18
KWCFRVCSRGSCYRRCRG

Formula C92H147N35O22S4

Absent Amino Acids ANDEQHILMPT

Common Amino Acids R

Mass 2223.64

PI 10.41

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +6

Boman Index 0.51

Hydrophobicity -0.778

Aliphatic Index 16.11

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 7240

Absorbance 280nm 325.59

Polar Residues 7

number

0

A

5

R

0

N

0

D

4

C

0

E

0

Q

2

G

0

H

0

I

0

L

1

K

0

M

1

F

0

P

2

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 1 V: 1

Length

18

Formula

C92H147N35O22S4

Mass

2223.64

PI

10.41

Net Charge

+6

Boman Index

0.51

Hydrophobicity

-0.778

C_terminal_Modification

Cyclized

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Host Defense Peptide

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 17.3 ± 1.0 µM

Detail Source Activity Anticancer

Activity Measurement 17.3

Target

Cancer Type Skin Cancer

Cell Line MM96L

Tissue Affected Skin

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 27.8 ± 2.2 µM

Detail Source Activity Anticancer

Activity Measurement 27.8

Target

Cancer Type Skin Cancer

Cell Line HT-144

Tissue Affected Skin

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 28.2 ± 2.0 µM

Detail Source Activity Anticancer

Activity Measurement 28.2

Target

Cancer Type Skin Cancer

Cell Line WM164

Tissue Affected Skin

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 4 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 13.2 ± 0.9 µM

Detail Source Activity Anticancer

Activity Measurement 13.2

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019