TPDB

3D PDB MODEL

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TPDB ID TPDB92378

Peptide_Name

Synthetic peptide

Activity

Antibacterial Anticancer Antifungal

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KWKKLLKKPPPLLKKLLKKL-NH2

FASTA

>TPDB92378|Antibacterial;Anticancer;Antifungal|length=20
KWKKLLKKPPPLLKKLLKKL-NH2

Formula C122H218N30O21

Absent Amino Acids ARNDCEQGHIMFSTYV

Common Amino Acids K

Mass 2441.26

PI 11.41

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +9

Boman Index 4.49

Hydrophobicity -0.710

Aliphatic Index 136.50

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 225.29

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

7

L

9

K

0

M

0

F

3

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 9 M: 0 F: 0 P: 3 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

20

Formula

C122H218N30O21

Mass

2441.26

PI

11.41

Net Charge

+9

Boman Index

4.49

Hydrophobicity

-0.710

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer, antibacterial, antifungal

Origin

Synthetic peptide

Evidence 1 Activity

Activity

Activity Raw

35% survival rate at 10 µM

Detail Source Activity Anticancer

Target

Cancer Type Lung Cancer

Cell Line Calu-6

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2004

Patents US_6800727_B2

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Raw

0% survival rate at 100 µM

Detail Source Activity Anticancer

Target

Cancer Type Lung Cancer

Cell Line Calu-6

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2004

Patents US_6800727_B2

Evidence 3 Activity

Activity

Activity Raw

~60% survival rate at 10 µM

Detail Source Activity Anticancer

Target

Cancer Type Blood Cancer

Cell Line Jurkat

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2004

Patents US_6800727_B2