TPDB

3D PDB MODEL

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TPDB ID TPDB92376

Peptide_Name

SVS-2

Activity

Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab dbAMP CellPPD-MOD CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KVKVKVKVPPTKVKVKVK-NH2

FASTA

>TPDB92376|Antibacterial;Anticancer;Antifungal;Cell-penetrating Peptides;Toxicity|length=18
KVKVKVKVPPTKVKVKVK-NH2

Formula C97H182N26O20

Absent Amino Acids ARNDCEQGHILMFSWY

Common Amino Acids K

Mass 2032.67

PI 11.36

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +8

Boman Index 9.45

Hydrophobicity -0.317

Aliphatic Index 112.78

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

8

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

7

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 7

Length

18

Formula

C97H182N26O20

Mass

2032.67

PI

11.36

Net Charge

+8

Boman Index

9.45

Hydrophobicity

-0.317

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic peptide

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Oral Cancer

Cell Line KB

Tissue Affected Oral mucosa

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-436

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012