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Peptide record

TPDB92375

[W2S]cT1 Antibacterial Anticancer Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92375
[W2S]cT1
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and PD_Hemolysis, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
KSCFRVCYRGICYRRCRG
Physicochemical Analysis
C93H152N34O22S4
ANDEQHLMPTW
R
2226.68
10.10
6
0
5
+6
0.98
-0.506
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
3230
145.06
7
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C93H152N34O22S4
2226.68
10.10
+6
0.98
-0.506
Cyclized
L
Cyclic
Cyclized
Host Defense Peptide
Synthetic
Evidence Records 6 records
Evidence 1 Activity

Activity

CC50
CC50 = 2.0 ± 0.1 µM
Anticancer
2.0

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

CC50
CC50 = 3.0 ± 0.2 µM
Anticancer
3.0

Target

Skin Cancer
HT-144
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

CC50
CC50 = 3.9 ± 0.2 µM
Anticancer
3.9

Target

Skin Cancer
WM164
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 4 Activity

Activity

CC50
CC50 = 18.9 ± 0.9 µM
Anticancer
18.9

Target

Skin Cancer
MDA-MB-435S
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 5 Activity

Activity

CC50
CC50 = 2.7 ± 0.2 µM
Anticancer
2.7

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 6 Activity

Activity

CC50
CC50 = 22.5 ± 2.1 µM
Anticancer
22.5

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019