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Peptide record

TPDB92363

p-Acl Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB92363
p-Acl
Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 CPPsite3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antiparasitic, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KKYKAYFKFKCKK-NH2
Physicochemical Analysis
C84H132N20O16S1
RNDEQGHILMPSTWV
K
1710.16
10.54
7
0
5
+7
2.38
-1.538
7.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
174.25
3
Residue Composition
number
1
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
7
K
0
M
2
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 7 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
13
C84H132N20O16S1
1710.16
10.54
+7
2.38
-1.538
Amidation
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Promastigotes L. (L.) Amazonensis Ph8, 2269 Strains And L. (L.) Infantum

Assay & Model

Female BALB/c mice aged 4–8 weeks
Female BALB/c mice aged 4–8 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
L. (L.) infantum intracellular amastigotes were less sensitive to p-Acl and p-AclR7 when compared to L. (L.) amazonensis.
Plasma membrane permeabilization
In vitro and in vivo
CCCCSCCCCSSCC
Additional Detail Fields 1 fields
CCCCSCCCCSSCC