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Peptide record

TPDB92359

Cyt c-ss-MAP Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92359
Cyt c-ss-MAP
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia AVPpred-BWR BBPpredict CellPPD CellPPD-MOD CPPsite3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, AVPpred-BWR, BBPpredict, and other sources, with an available 3D structural model.
N-terminal: Conjugated to Radiolabeled cytochrome c with disulphide linkage
Sequence
KLALKLALKALKAALKLA
Physicochemical Analysis
C90H169N23O19
RNDCEQGHIMFPSTWYV
L
1877.47
11.12
5
0
13
+5
0.01
0.994
185.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C90H169N23O19
1877.47
11.12
+5
0.01
0.994
L
Amphipathic
Linear
Conjugated to Radiolabeled cytochrome c with disulphide linkage
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEK293 cells and HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Protein (Cyt C protein)
Nucleus
38-fold higher uptake for Cyt c-ss-MAP compared to unmodified Cyt c was observed
Endocytosis
In vitro
CCTTTCTHHHHHHHTTCC
Additional Detail Fields 1 fields
CCTTTCTHHHHHHHTTCC