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Peptide record

TPDB92353

MAP PN159 (or) KLAL (or) MAP PN159 (SEQ ID NO: 13) Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92353
MAP PN159 (or) KLAL (or) MAP PN159 (SEQ ID NO: 13)
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia AVPpred-BWR BBPpredict CellPPD CellPPD-MOD CPPsite3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, AVPpred-BWR, BBPpredict, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KLALKLALKALKAALKLA-NH2
Physicochemical Analysis
C90H169N23O19
RNDCEQGHIMFPSTWYV
L
1877.47
11.12
5
0
13
+5
0.01
0.994
185.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C90H169N23O19
1877.47
11.12
+5
0.01
0.994
Amidation
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCTTTCTHHHHHHHTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cells , MCF-7 And SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
Tacrine
In vitro
CCTTTCTHHHHHHHTTCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells Bacteroidetes (Bacteroides Vulgatus And Bacteroides Thetaiotaomicron), Firmicutes (Lactobacillus Gasseri, Latilactobacillus Sakei, And Clostridium Bolteae), Actinomicetya (Bifidobacterium Longum, And Bifidobacterium Adolescentis) , Proteobacteria (Escherichia Coli Nissle 1917 And Escherichia Coli K12) And Saccharomyces Boulardii

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
FITC-dextran
In vitro
CCCCSCCCCCSSSCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y and Caco-2 cell line

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
NLCs loaded drugs (tacrine (TAC), rasagiline (RAS), and tranylcypromine (TCP))
In vitro
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Additional Detail Fields 1 fields
CCTTTCTHHHHHHHTTCC CCCCSCCCCCSSSCCC CCCCCCSSCCSCCSCHHHHHHTGGGCC