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Peptide record

TPDB92348

B3 Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92348
B3
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KKLFKKILKYLKKL-NH2
Physicochemical Analysis
C90H159N21O16
ARNDCEQGHMPSTWV
K
1791.38
10.95
7
0
7
+7
2.31
-0.436
139.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
83.18
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
7
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 7 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C90H159N21O16
1791.38
10.95
+7
2.31
-0.436
Amidation
L
Linear
Free
Antimicrobial
Analogue of BP 100
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 47.4 ± 12.5 µM
Anticancer
47.4

Target

Leukemia Cancer
K-562
Blood

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2017

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 25.3 ± 3.2 µM
Anticancer
25.3

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2017
Evidence 3 Activity

Activity

IC50
IC50 = 28.4 ± 3.1 µM
Anticancer
28.4

Target

Breast Cancer
MCF-7/ADM
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2017