TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB92344

Peptide_Name

C16-Lipotetrapeptide

Activity

Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

Peptipedia CancerPPD 2.0 CAFPdb CPPsite3.0 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Palmitic acid

Sequence

KKKK-NH2

FASTA

>TPDB92344|Antibacterial;Anticancer;Antifungal;Cell-penetrating Peptides;Hemolysis;Toxicity|length=4
KKKK-NH2

Formula C24H50N8O5

Absent Amino Acids ARNDCEQGHILMFPSTWYV

Common Amino Acids K

Mass 530.71

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +4

Boman Index 3.96

Hydrophobicity -3.900

Aliphatic Index 0.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

4

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C24H50N8O5

Mass

530.71

PI

11.00

Net Charge

+4

Boman Index

3.96

Hydrophobicity

-3.900

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Palmitic acid

Nature

Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 30 µM

Detail Source Activity Anticancer

Activity Measurement 30 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay MTS assay

Testing Time 73-76h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 30 µM

Detail Source Activity Anticancer

Activity Measurement 30 µM

Target

Cancer Type Breast Cancer

Cell Line JIMT-1

Tissue Affected Breast

Assay & Model

Assay MTS assay

Testing Time 73-76h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Evidence 3 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 18 µM

Detail Source Activity Anticancer

Activity Measurement 18 µM

Target

Cancer Type Prostate Cancer

Cell Line DU-145

Tissue Affected Prostate

Assay & Model

Assay MTS assay

Testing Time 73-76h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015