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Peptide record

TPDB92334

PACAP PACAP 38 Antibacterial Antifungal Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB92334
PACAP PACAP 38
Antibacterial Antifungal Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
Peptipedia AFP-GFuse CAFPdb BBPpredict CellPPD-MOD CPPsite3.0 MLCPP 2.0
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, AFP-GFuse, CAFPdb, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
Physicochemical Analysis
C203H330N62O54S1
CEPW
K
4535.30
10.79
12
2
15
+9
8.87
-1.061
61.58
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5960
131.41
11
Residue Composition
number
3
A
4
R
1
N
2
D
0
C
0
E
2
Q
2
G
1
H
1
I
2
L
7
K
1
M
1
F
0
P
3
S
1
T
0
W
4
Y
3
V
Amino Acid Distribution
A: 3 R: 4 N: 1 D: 2 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 1 L: 2 K: 7 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 4 V: 3
Chemical Descriptors
38
C203H330N62O54S1
4535.30
10.79
+9
8.87
-1.061
Amidation
L
Cationic
Linear
Free
N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O.C N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 and CHO-pgs-A-745

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (Fluorescien)
Macropinocytosis
In vitro
CCSSSSCCHHHHHHHHHHHHHHHHHSTTTTHHHHCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC labelled
5- to 10-fold higher cellular uptake than others
GAGs-dependent endocytosis
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCSSSSCCHHHHHHHHHHHHHHHHHSTTTTHHHHCCC CCCCCCCCC