TPDB

3D PDB MODEL

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TPDB ID TPDB92330

Peptide_Name

Longicalycinin A cyclic analogue 3

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

GYPFA

FASTA

>TPDB92330|Antibacterial;Anticancer;Toxicity|length=5
GYPFA

Formula C28H35N5O7

Absent Amino Acids RNDCEQHILKMSTWV

Common Amino Acids AGFPY

Mass 553.62

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.78

Hydrophobicity 0.260

Aliphatic Index 20.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 269.14

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C28H35N5O7

Mass

553.62

PI

5.94

Net Charge

-0

Boman Index

-1.78

Hydrophobicity

0.260

C_terminal_Modification

Cyclized

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Anticancer

Origin

Synthetic Analogue of Longicalycinin A

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.5 ± 0.0056 µg/ml

Detail Source Activity Anticancer

Activity Measurement 9.5

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.28 ± 0.0063 µg/ml

Detail Source Activity Anticancer

Activity Measurement 11.28

Target

Cancer Type Colorectal Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 3 Activity

Activity

Activity Raw

56.72% Cell death at 100 µg/ml

Detail Source Activity Anticancer

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 4 Activity

Activity

Activity Raw

28.51% Cell death at 100 µg/ml

Detail Source Activity Anticancer

Target

Cancer Type Colorectal Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020