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Peptide record

TPDB92326

sC18ΔE Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92326
sC18ΔE
Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, CPPsite3.0, and PD_Hemolysis, with an available 3D structural model.
C-terminal: Amidation
Sequence
GLRKRLRKFRNKIKK-NH2
Physicochemical Analysis
C87H161N33O17
ADCEQHMPSTWYV
K
1941.45
12.89
9
0
4
+9
6.06
-1.767
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C87H161N33O17
1941.45
12.89
+9
6.06
-1.767
Amidation
L
Amphipathic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293 , MCF-7 And Hff-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein and Doxorubicin
Cytoplasm
Highly significant and enhanced internalization
Endocytosis
In vitro
CCSCGGGGTTSCSSCCEESSSCEEC
Additional Detail Fields 1 fields
CCSCGGGGTTSCSSCCEESSSCEEC