TPDB

3D PDB MODEL

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TPDB ID TPDB92322

Peptide_Name

Mra30

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 30-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, CancerPPD 2.0, and ToxinPred 3.0, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

GIPCGESCVFIPCLTSAIGCSCKSKVCYRN

FASTA

>TPDB92322|Antibacterial;Anticancer;Toxicity|length=30
GIPCGESCVFIPCLTSAIGCSCKSKVCYRN

Formula C132H216N36O40S6

Absent Amino Acids DQHMW

Common Amino Acids C

Mass 3139.74

PI 8.02

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +2

Boman Index 1.79

Hydrophobicity 0.547

Aliphatic Index 74.67

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1865

Absorbance 280nm 59.40

Polar Residues 13

number

1

A

1

R

1

N

0

D

6

C

1

E

0

Q

3

G

0

H

3

I

1

L

2

K

0

M

1

F

2

P

4

S

1

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 2 M: 0 F: 1 P: 2 S: 4 T: 1 W: 0 Y: 1 V: 2

Length

30

Formula

C132H216N36O40S6

Mass

3139.74

PI

8.02

Net Charge

+2

Boman Index

1.79

Hydrophobicity

0.547

C_terminal_Modification

Cyclized

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Antimicrobial and Anticancer

Origin

Viola tricolor, Melicytus ramiflorus, Viola philippica

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 4.91 ±0.04 µM

Detail Source Activity Anticancer

Activity Measurement 4.91

Target

Cancer Type Skin Cancer

Cell Line MM96L

Tissue Affected Skin

Assay & Model

Assay Resazurin dye assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 15.5 ±0.06 µM

Detail Source Activity Anticancer

Activity Measurement 15.5

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay Resazurin dye assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 1.75 ±0.05 µM

Detail Source Activity Anticancer

Activity Measurement 1.75

Target

Cancer Type Gastric Cancer

Cell Line BGC-823

Tissue Affected Stomach

Assay & Model

Assay Resazurin dye assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015